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The extent of absorption of cocaine into your systemic circulation just after nasal insufflation is analogous to that immediately after oral ingestion. The rate of absorption just after nasal insufflation is restricted by cocaine-induced vasoconstriction of capillaries while in the nasal mucosa. Onset of absorption soon after oral ingestion is delayed simply because cocaine is a weak foundation with a pKa of eight.6, which is Therefore in an ionized type that is definitely inadequately absorbed with the acidic tummy and easily absorbed in the alkaline duodenum.[eleven] The speed and extent of absorption from inhalation of cocaine is comparable or larger than with intravenous injection, as inhalation offers entry directly to the pulmonary capillary mattress.
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